Contains germline missense mutation data retrieved from the ClinVar database (October 2024 release; review status ≥ 1 star), mapped with interface annotations.

Integrates PASS-filtered missense variant data from gnomAD (v2.1.1), annotated with interfaces.

Aggregates whole-exome sequencing data from 50,000 individuals in the UK Biobank (filtering exclusively for PASS missense variants), including interface annotations.

Comprehensive variant data mapped to interface sites across ClinVar, gnomAD, and UK Biobank to evaluate functional impact on protein interactions.