The First Proteome-Wide Atlas of Protein-Protein Interaction Interfaces and Pathogenic Mutations.

Protein-Protein Interaction

Protein–protein interactions (PPIs) are the physical contacts formed between two or more protein molecules, allowing them to work together to carry out essential biological functions. These interactions regulate nearly every cellular process—such as signaling, metabolism, immune response, and gene expression. Understanding PPIs helps researchers uncover how cells function, how diseases develop, and how new therapeutic strategies can be designed.

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20,656 Proteins

9,854,603 Residues

1,168,160 Predicted Interface Sites

XXX, XXX Annotated Pathogenic Variants

Brief-introduction-of-Protein-Protein-Interaction-0

PPI_esm2_t33_650M_UR50D

a deep-learning model used for predicting protein–protein interactions (PPIs). It is built on top of ESM-2, a family of protein language models developed by Meta AI.